Molecular biological character of PRL-3 and its relationship with colorectal cancer metastasis
- VernacularTitle:PRL-3磷酸酶分子生物学特性及其与大肠癌转移
- Author:
Pingping REN
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Rectal neoplasms;
PRL-3;
Metastasis
- From:
Journal of International Oncology
2008;35(5):375-378
- CountryChina
- Language:Chinese
-
Abstract:
The phosphatase of regenerating liver(PRL)families of phosphatases,consisting of PRL-1,PRL-2,and PRL-3,are individually overexpressed in a variety of cancer cell lines and tissues when eom-pared with their normal counterparts.Several recent studies have shown that PRL-3 is expressed at a higher lev-el and at a greater frequency in colorectal cancer with liver metastases compared with primary colorectal tumorsand normal colon tissue.Expression of PRL can enhance metastatic and invasive properties of cells and initiate tumor angiogenesis in experimental mice.However,the exact mechanism and in- teracting proteins of the PRL remain unclear.With further study,PRL-3 may server as an attractive target for therapeutic intervention and marker for colon cancer metastasis.
