Value of serum and saliva anti-α-fodrin antibodies in patients with sjfigren's syndrome
- VernacularTitle:血清和唾液抗α-胞衬蛋白抗体检测及其在干燥综合征中的意义
- Author:
Ke XU
;
Yunxia HOU
;
Lin ZHANG
;
Hua WEI
;
Chunyang ZHA
;
Wenpeng ZHAO
;
Yuehong HUO
;
Xuefang HU
;
Xiaofeng LI
- Publication Type:Journal Article
- Keywords:
Sj(o)gren's syndrome;
-α-fodrin;
Serum;
Saliva
- From:
Chinese Journal of Rheumatology
2008;12(6):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of IgA and IgG antibodies against α-fodrin in both serum antibodies in SS is also assessed.Methods Samples from 39 patients with SS(25 primary and 14 secondary),8 patients with systemic lupus erythematosus(SLE),and 15 patients with rheumatoid arthritis (RA)as well as 10 healthy blood donors were collected.Anti-α-fodrin antibodies were measured using ELISA.Results The titer of serum anti-α-fodrin was higher in SS than in other connective tissue diseases group and healthy group(P<0.01).IgA type anti-α-fodrin antibodies was detected in 60%.44% of serum and saliva in patients with pSS respectively.IgG antibodies were detected in 43% of sera,and 29% of saliva of patients with pSS.The sensitivity and specificity of serum anti-α-fodrin IgA in SS was 54%and 85%.The level of anti-α-fodrin was positively associated with xerostomia and parotid swelling (P<0.05),and was negatively associated with xeroma,renal tubule acidosis,lung interstitial disease and hepatic damages(P>0.05).Conclusion Saliva and serLlm anti-α-fodrin level may be diagnostic for SS.It may be a useful screening marker.
