Apply the accelerated stability test to predict the self-life of national standard serum tetanus antitoxin
- Author:
Nguyen Thi Kim Huong
- Publication Type:Journal Article
- Keywords:
Accelerated stability test;
Serum tenanus antitoxin;
National standard;
Application;
- MeSH:
Tetanus Antitoxin;
Diagnosis
- From:Journal of Preventive Medicine
2005;15(1):14-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Accelerated stability test has been applied for predicting self-life of national standard serum tetanus anti-toxin (SAT). Samples of the tetanus antitoxin were kept at - 20°C, 4°C, 22°C, 37°C and 45°C for 6 months and their potency was estimated by using the toxin neutralization method on mice. There was relationship between the potency change and the self- life of serum tetanus antitoxin by using Arrhenius equation. The results demonstrated that the self-life of the national standard serum tetanus antitoxin was 9 years and 6 months when stored at -20°C.
