Clinical analysis on rheumatoid arthritis treated with disease modifying antirheumatic drug
- VernacularTitle:改善病情抗风湿药治疗类风湿关节炎167例临床分析
- Author:
Wen XIE
;
Rong SHU
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Antirheumatic agents;
Treatmerrt outcome
- From:
Chinese Journal of Rheumatology
2008;12(6):410-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical outcomes of rheumatoid arthritis (RA) patients treated with different disease modifying antirheumatic drugs (DMARD) by analysing the clinical data and improve the understanding of different DMARDs.Methods The clinical data of RA patients who were treated and followed-up during Jan.1999 to Mar.2003 in Peking Union Medical College Hospital were retrospectively reviewed.The clinical efficacy and radiotogical changes were compared between patients treated with one DMARD only,2 DMARDs combination and 3 DMARDs combination.The short-term and long-term effects among different dosage regimens in the three groups,and the long-term results of different duration of DMARD treatment were also compared.Resuits Three hundred and twenty-night patients had their clinical and follow-up data available for analysis.Among them,256 patients had DMARDs as their initial treatment.Some of the patients showed eorticosteroid in their treatment regimen while some patients did not have steroid.The clinical effectiveness had no significant difference between patients who had corticosteroid or not.Patients treated with 2 or more DMARDs combination had more improvement in ESR,CRP level,morning stiffness and number of swollen and tender joints compared with one DMARD alone.There was no significant difference in adverse reactions between the 3 groups treated with DMARDs.Conclusion DMARDs combination treatment can significantly and rapidly improve the symptoms and lab parameters in RA.
