Apoptin induces apoptosis in tumor cells
- VernacularTitle:凋亡素及其诱导肿瘤细胞凋亡的作用
- Author:
Yifan WANG
;
Zhuojing HE
- Publication Type:Journal Article
- Keywords:
Apoptin;
Neoplasms;
Apoptosis
- From:
Journal of International Oncology
2008;35(5):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Apoptin,a chicken anemia virus-derived protein.selectively induces apoptosis in trans-formed or tumor cells but not in normal cells.The tumor specificity of apoptin is thought to be related to its cel-lular localization.The apoptin-induced apoptosis is p53-independent and can not be blocked by overexpressionof Bcl-2.But activation of Caspase-3 is essential for apoptin-induced apoptosis.These features make apoptin a potential candidate as a novel therapeutic and diagnostic tool in cancer treatment.
