p27、cyclinD1 and malignant cancer
- VernacularTitle:p27、cyclin D1与恶性肿瘤
- Author:
Jing LI
;
Linlin YIN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
CyclinD1;
Cell cycle
- From:
Journal of International Oncology
2008;35(5):336-339
- CountryChina
- Language:Chinese
-
Abstract:
The genesis of malignant tumor is proved to be mainly caused by regulatory disturbance of cell cycle,in which p27 protein and cyclin D1 protein are major regulators.Cyclin D1 and p27 are positive andnegative regulator respeetively.Recently,redueed expression of p27 protein and overexpression of cyclinD1 pro-tein are found in various eaacers.It has been demonstrated that p27and cyelinD1 are closely associated with the genesis and development of many cancers.Cell cycle and its regulatory has become the focus in tumor research.
