The expression of HER4 in renal cell carcinoma
- VernacularTitle:人表皮生长因子4在肾癌组织中的表达及与肾癌生物学行为的关系
- Author:
Qilong MIAO
;
Yiming YU
;
Yunshan TAN
;
Yonghua XU
;
Zaichun DENG
- Publication Type:Journal Article
- Keywords:
Kidney neoplasms;
Carcinoma;
Genes;
Immunohistochemistry
- From:
Chinese Journal of Urology
2008;29(6):402-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of HER4 in renal cell carcinoma and elucidate therelationship between HER4 expression and the clinical features of renal cell carcinoma. Methods Seventy-five cases of paraffin-embedded tissues from renal eell carcinoma were tested for the expres-sion of HER4 by immunohistochemistry.Forty-six cases were male,29 cases were female,the median age was 49 years old.All of these cases were diagnosed as renal cell carcinoma(51 cases of clear cell carcinoma,1 5 cases of granular cell carcinoma,and 9 cases of papillary adenocarcinoma).The control group was 20 cases of normal renal tissue 5 am away from the tumor.Descriptive analysis was applied to compare the differences used the x2.test.Statistical analysis was done by SPSS 10.0. Results HER4 was overexpressed in 78.7%RCC(9 cases with weak positive,18 cases moderate positive,41 caseS intensive positive and 7 cases negative)cases.The expression of HER4 was negative in all nor-mal tissue.The overexpression of HER4 was correlated with the lymph node metastasis and TNM staging(P<0.05). Conclusions HER4 overexpressionis correlated with Stage of RCC.
