Urodynamics and ultrastructure of detrusor in patients with benign prostatic hyperplasia
- VernacularTitle:良性前列腺增生患者尿动力学及逼尿肌超微结构的相关性研究
- Author:
Jinsheng ZHANG
;
Ning LIU
;
Yuan QU
;
Zongshan WU
;
Qian ZHANG
;
Jun CHAI
;
Chunlin LIU
- Publication Type:Journal Article
- Keywords:
Benign prostatic hyperplasia;
Bladder detrusor;
Ultrastructure
- From:
Chinese Journal of Urology
2008;29(6):422-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between urodynamics and ultrastructure of bladder detrusor in patients with benign prostatic hyperplasia(BPH). Methods The ultrastructure of detrusor was studied by transmission electron microscopy in 43 cases of BPH(mean age 69.5±6.0 years)and 21 cases(mean age 65.4±7.2 years)of geriatric without bladder outlet obstruction(the controls).All the cases were performed urodynamic test. Results The IPSS(21.1±3.0 VS 7.6±1.4),maximum flow rate(7.7±1.3 ml/s VS 14.9±2.3 ml/s)and AG(44.8±9.9 VS 19.0±5.9)showed significant differences between the the BPH group and control group(P<0.01).Pdet-Qmax in the BPH group(60.1±11.0 cm H20)was higher than that in the control group(48.7±7.1 cm H2o) (P<0.05).The relative density of mitochondria in the BPH group(0.81±0.24)was lower than that in the control group(1.03±0.11)(P<0.05).The intercellular linkage in the BPH group(19.4±4.8 rim)was larger than the control group(14.1±2.0 nm)(P<0.05). Conclusions The swelling and reduction of the relative density of mitochondria could be seen in the bladder detrusor of BPH patients.The large intercellular linkage might be the reason of decrease the coordinate contractility of the blad-der detrusor.
