Cancer stem cell and CD133
- VernacularTitle:肿瘤干细胞及其与CD133的关系
- Author:
Bifeng TANG
- Publication Type:Journal Article
- Keywords:
Tumor stern cells;
Neoplasms;
CD133
- From:
Journal of International Oncology
2008;35(5):326-329
- CountryChina
- Language:Chinese
-
Abstract:
Recent evidence has increasedly supposed cancer stem cell theory.that cancers can be viewed as an abnormal organ in which tumor growth is driven by a population of cancer stem cells,with self-re-hewing and muti-differentiation potentiality.CD133 has been repofled sequentially in many malignan-cies.Although the biological function of CD133 is not well understood.the CD133 epitope cueeently senves as a useful marker for the isolation of cancer stem cells.Research has discovered that CD133+ tumor cells are in re-lation to tumorigenesis,invasion,metastasis,drug-resistance and recurrence.So,understanding the molecular bi-ology of the CD133+ tumor cells is essential for developing more effective anti-cancer tIeatments,especiallv tar-geting cancer stem cells.
