DNA repair mechanisms of tumor cells and chemotherapy sensitivity
- VernacularTitle:肿瘤细胞DNA损伤修复机制与化疗敏感性
- Author:
Pengjun ZHANG
- Publication Type:Journal Article
- Keywords:
DNA repair;
Chemosensitivity;
Drug resistance;
Polymorphism,single nucleotide
- From:
Journal of International Oncology
2008;35(5):346-348
- CountryChina
- Language:Chinese
-
Abstract:
DNA damage caused by chemotherapeutic drugs plays an important role in the tumor chemo- therapy.The DNA repair pathways that are activated in response to DNA damage induce resistance to chemo-therapeutic drugs or radiation and depress the effect of these agents on tumor cells.Down-regulated DNA repair capacity has shown a better effect through inducing tumor cell hypersensitivity to chemotherapeutic drugs.It has emerged as an important comprehensive approach by down-regulated expression of DNA repair genes in the treatment of cancer.
