Monitoring and evaluating on cell injury in patients with severe trauma
- VernacularTitle:创伤后细胞损伤的监测与评价
- Author:
Lihua TIAN
;
Duan HU
;
Xiangjun BAI
;
Xiyuan ZHOU
;
Hong ZHAO
- Publication Type:Journal Article
- Keywords:
Wounds and injuries;
Cell injury;
Multiple organ dysfun ction syndrome (MODS);
Trauma score
- From:
Chinese Journal of Emergency Medicine
2008;17(6):627-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in cytokines, oxygen free radicals, acidulous production in serum and to investigate the effectiveness of monitoring metabolism of cells and the method for evaluating cell injury in patients with severe trauma. Method The detailed data of 117 patients rescued and managed carefully from May 2005 to February 2007 were assessed and stratified with ISS and APACHE Ⅱ , and the serum levels of arterial blood lactate(ABL) ,base deficit(BD) ,superoxide(SOD) ,lipid peroxide(LPO) ,TNF-α and IL-6 were measured in real-time according to the condition of the patient. Results The monitoring biomarkers obviously changed with injury severity which endangered the situation of patients after trauma (P < 0.05) , especially in the patients with ischemia , hypoxia, shock, iniection, SIRS, and MODS (P < 0.01). The persistence of extremely elevated levels of biomarkers meant the organ failure and fatality of patients after trauma, and there was a obvious differece between those cases and cases without elevation of biomarkers ( P < 0.01). Conclusions The outcome of patients after trauma is closely correlated with injury severity,infection and MODS,and the levels of biomarkers including ABL, SOD, IPO, TNF-a and IL-6 are useful indicators of outcome measure.
