PCR Study for Human Herpesvirus 8 in Korean Patients with Several Cutaneous Diseases.
- Author:
Kyoung Ae JANG
1
;
Se Jin AHN
;
Hwa Jung LEE
;
Jee Ho CHOI
;
Kyung Jeh SUNG
;
Kee Chan MOON
;
Jai Kyoung KOH
Author Information
1. Department of Dermatology, Seoul Paik Hospital.
- Publication Type:Original Article
- Keywords:
Human herpesvirus 8 (HHV8);
Kaposi's sarcoma;
Sarcoidosis;
Kikuchi's disease;
Angiosarcoma;
Angiolymphoid hyperplasia with eosinophilia
- MeSH:
Angiolymphoid Hyperplasia with Eosinophilia;
Base Sequence;
Chungcheongnam-do;
DNA, Viral;
Giant Lymph Node Hyperplasia;
Hemangiosarcoma;
Herpesvirus 8, Human*;
Histiocytic Necrotizing Lymphadenitis;
Humans*;
Lymphoma, Primary Effusion;
Medical Records;
Polymerase Chain Reaction*;
Sarcoidosis;
Sarcoma;
Sarcoma, Kaposi;
Skin Diseases
- From:Korean Journal of Dermatology
2000;38(9):1162-1167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The association of Kaposi's sarcoma-associated human herpesvirus, or human herpesvirus 8 (HHV8) with various skin diseases has been described in many reports. However, only 3 human diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease were proved to be associated with HHV8. In addition to Karposi's sarcoma, sarcoidosis and Kikuchi's disease were also described to be associated with HHV8. OBJECTIVE: The purpose of this study was aimed at the association of HHV8 with various skin diseases, such as Kaposi's sarcoma, sarcoidosis, and Kikuchi's disease. METHODS: We performed PCR to examine whether the 233-bp segment of the viral DNA of HHV8 was detected in Korean patients with Kaposi's sarcoma, sarcoidosis, Kikuchi's disease, angiosarcoma, and angiolymphoid hyperplasia with eosinophilia. The medical records and histopathological specimens of patients diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. RESULTS: HHV8 DNA sequences were identified in 9 (69%) of sarcoid tissues from 12 patients with sarcoidosis and in all (100%) of from 8 patients with Kaposi's sarcoma but not in 2 tissues from 2 patients with Kikuchi's disease, in 3 tissues from 2 patients with angiosarcoma and 2 tissues from 2 patients with angiolymphoid hyperplasia with eosinophilia. CONCLUSION: HHV8 may be strongly associated with the pathogenesis of Kaposi's sarcoma and sarcoidosis. However, the association with Kikuchi's disease, angiosarcoma, and angiolymphoid hyperplasia with eosinophilia was denied in this study. Further extensive study will be needed.
