The expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in muscle tissue of inflammatory myopathies
- VernacularTitle:肿瘤坏死因子相关凋亡诱导配体及其受体在特发性炎性肌病患者骨骼肌的表达
- Author:
Hua ZHAO
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Myositis;
Tumor necrosis factor-related apoptosis inducing ligand
- From:
Chinese Journal of Internal Medicine
2008;47(5):369-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to analyse the expression of tumor necrosis factor (TNF)-related apoptosis inducing ligand(TRAIL)and its receptors in muscle tissue from patients with idiopathic inflammatory myopathies(ⅡM)and investigate the possible role of TRAIL system in the Dathogenesis of IIM.Methods TRAIL and its receptors DR4,DR5,DCRl and DCR2 were detected in the musck biopsy tissue from 36 patients with ⅡM(13 polymyositis,23 dermatomyositis)and 9 heMthy controls bv using immunohistochemistry. Results The expression of TRAIL and its receptors was f10und in muscle tissue samples from the IIM patients and healthy controls.The expression of TRAIL,DR4 and DCR2 in the muscle tissue from the IIM patients was significantly higher than those from healthy controls(all P values< 0.05).The expression of TRAIL,DCRl and DR4 was also detected in the infiltrating lymphocytes in endomysium and in the interstitial tissue around blood vessels.Conclusion The diversity in expression of TRAIL and its receptors between patients with IIM and healthy controls suggests the hypothesis of a crucial role of TRAIL in the pathogenesis and the pathology of IIM.
