Clinical analysis of 29 hyperthyroid patients combined with cytopenia
- VernacularTitle:甲状腺功能亢进症合并血细胞减少症29例临床分析
- Author:
Xiaolan ZHANG
;
Yu DUAN
;
Li ZHANG
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Paneytopenia
- From:
Chinese Journal of General Practitioners
2008;7(6):412-413
- CountryChina
- Language:Chinese
-
Abstract:
This report was to retrospectively analyze clinical data of 29 hyperthyroid patients with concurrent hematocytopenia.Our findings demonstrated that 5 patients developed cytopenia without any antithyroidism drugs(ATDs),while the other 24 cytopenia patients were only found after taking ATD.In the drug intervention group,17 patients received methimazole(MMI)and 7 took propylthiouracil(PTU).Most cytopenia was dose-dependent and occurred within the first 6 months of medication.Twenty subjects received radioiodine therapy,with no impact on blood cells.We suggested that cytopenia might occur at the early stage of ATD therapy and be related with drug and its dose.Blood cell amount should be monitored,especially for initial ATD therapy.As for interaction between PTU and MMI,alternative radioiodine therapy might seem to be relatively safe.
