Effects of Taizhian treatment on the macrophages in the plague ofaotic intima and the levels of blood lipid in hypercholesterolemic rabbits
- VernacularTitle:泰脂安对高胆固醇血症兔血脂和主动脉内膜中巨噬细胞的影响
- Author:
Shu DUAN
;
Ping DENG
;
Shuiping ZHAO
;
Qingchun LIANG
- Publication Type:Journal Article
- Keywords:
Ligustrum;
Hypercholesterolemia;
Diet,atherogenic
- From:
Chinese Journal of Geriatrics
2008;27(6):471-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Taizhian treatment on macrophages expression in the plaque of aotic intima and blood lipid levels in hypercholesterolemic rabbits. Methods Sixteen male New Zealand rabbits were given 1%high-cholesterol diet. After 8 weeks,these macrophages expression in aotic intima was detected by immunohistochemistry. Results Compared with normal rabbits,Taizhian treatment decreased the expression of macrophages in aortic intima by 25%and reduced serum levels of low density lipoprotein-cholesterol by 21%in hypercholesterolemic rabbits(both P<0.05). Conclusions Taizhian may significantly decrease blood lipid level and reduce atherosclerosis in hypercholesterolemic rabbits.
