Immunohistochemical Study of TGF- type I and type II receptor Expression in Psoriatic Epidermis.
- Author:
Jeung LEE
1
;
Young Keun KIM
;
Sang Wahn KOO
;
Gwang Seong CHOI
Author Information
1. Department of Dermatology, Inha University College of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Transforming growth factor;
TGF-beta receptor;
Psoriasis
- MeSH:
Down-Regulation;
Epidermis*;
Epithelial Cells;
Humans;
Immune Sera;
Intercellular Signaling Peptides and Proteins;
Psoriasis;
Receptors, Transforming Growth Factor beta;
Signal Transduction;
Skin;
Transforming Growth Factor beta;
Transforming Growth Factors
- From:Korean Journal of Dermatology
2000;38(9):1205-1211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Previous studies have demonstrated the pathogenetic role and expression of TGF-beta in psoriatic lesion. Transforming growth factor s are a family of growth factors with inhibitory effects on epithelial cell proliferation. Their effects are mediated by two interacting receptors, of which type I receptor mediates signal transduction after interaction with type II receptor carrying the TGF ligand. OBJECTIVE: The purpose of this study was to investigate the relationship between development of psoriasis and expression of TGF-beta receptors in psoriatic lesion. METHODS: We have studied the expression of TGF-beta type I and type II receptors in psoriatic lesions of 30 psoriatic patients who had not been treated for 1 month, 5 non-lesional psoriatic skin, and 3 normal human skin by immunohistochemical staining using polyclonal rabit antisera. RESULTS: 1. Immunohistochemical analysis revealed an intense immunoreactivity for TGF-beta type I and type II receptors in the basal and also suprabasal layer of normal epidermis and non-lesional psoriatic skin. 2. Almost all psoriatic lesions studied lacked detectable immunoreactivity of either receptor in the epidermis. CONCLUSION: We suggest the lack of TGF-beta - mediated growth inhibition by down regulation of TGF-beta receptor expression may play an important role in the pathogenesis of psoriasis.
