Study on the antihypertensive and renoprotective effects of valsartan
- VernacularTitle:缬沙坦对降血压和保护肾脏的作用研究
- Author:
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Valsartan;
Diabetic nephropathies;
Hypertension
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(5):776-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efffects of angiotensin Ⅱ receptor antagonist (ARB) valsartan in decreasing blood pressure and protecting kidney to the patients suffering from mild-or-moderate hypertension companied with earlier type 2 diabetic nephropathy. Methods The patients suffering from mild-to-moderate hypertension and earlier type 2 diabetic nephropathy were divided into two groups. One of the groups were treated by valsartan, and the other were treated by betaloc and aldadinc. The period of the treatment and doses of the medicines were adjusted depending on the blood pressure 4 weeks later. The therapeutic effects of the two medicines were analyzed 6 months later. Results There was no difference in the effects of decreasing blood pressure and side-effects between the two groups. There are marked discrepancy between the two groups in the post-trearment 24h urinary albumin excretion rate (UAER) and the variation of 24h UAER (all P<0.05). There was no significant difference in others parameters (all P0.05). Conclusion Valsartan could prevent early proteinuria of type 2 diabetic nephropathy from developping and protect the function of kidney.
