Combined detection of CYFRA21-1 and β2-MG for differentiation of malignant pleural effusions
- VernacularTitle:角蛋白片段抗原和β2微球蛋白联合检测对癌性胸腔积液的诊断价值
- Author:
Xianbin YANG
;
Bin YI
- Publication Type:Journal Article
- Keywords:
Pleural effusion,malignant;
Lung tumor;
Cytokeration fragment antigen 21-1;
β2-microglobulin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(5):790-791
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the significance of CYFRA21-1 and β2-microglobulin expression in pleural fluid and develop diagnostic application for malignant pleural effusion differentiation. Methods Detected expression of CYFRA21-1 by RIA analysis and β2-MG by immunoturbidimetry assay (ITA), in 40 cases of benign pleural effusion and 40 cases of malignant pleural effusion. Results The mean level of CYFRA21-1 in malignant pleural effusions was (78.80±24.90)μg/L higher than that in benign pleural effusions (26.20±15.60)μg/L (P<0.05) and β2-MG in benign pleural effusions was (6.11±0.87)mg/L, significantly higher than that in malignant pleural effusions which was (3.12±0.91)mg/L respectively (P<0.05). Conclusion Evaluation of CYFRA21-1 and β2-MG in chest fluid can improve the differential diagnosis of malignant pleural effusion from benign pleural effusion and significantly increase the sensitivity of diagnosis.
