Effects of curosurf on neonatal respiratory distress syndrome by different administration means
- VernacularTitle:猪肺磷脂不同应用方式对新生儿呼吸窘迫综合征的影响
- Author:
Yiqun TENG
;
Xia YAN
;
Yan LU
;
Jinxiang YAO
;
Qiong WANG
;
Qiuying HOU
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome;
Pulmonary surfactant-associated protein-A;
Infants;
newborn
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(5):792-794
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative and prophylactic effects of pulmonary surfactant (PS) on neonatal respiratory distress syndrome (NRDS) by two different administration means. Methods 35 neonates with NRDS were divided into groups Ⅰ and Ⅱ randomly, prophylactic group were randomly divided into groups Ⅲ and Ⅳ, the means of administration in all patients was through tracheal tube. Neonates in group Ⅰ and Ⅲ, were given curosurf in several times with different posture, group Ⅱ and IV were given in one time with supine position. Blood gas analysis, index of mechanical ventilation, the duration of mechanical ventilation, hours of oxygen requirement and hospitalization between Ⅰ and Ⅱ group, the incidence of NRDS between Ⅲ, and IV group were analyzed and compared before and after treatment. Results After treatment for 6 and 24 hours, the oxygenation and lung function of group Ⅰ and Ⅱ improved respectively (P<0.05), the total times of assisted ventilation, Supplemental oxygen therapy and hospitalization were significantly decreased, the differences of those index were no significant between Ⅰ and Ⅱ group (P0.05), the incidence of NRDS have no different between Ⅲ and IV group. Conclusion Pulmonary surfactant is effective and safe for treating and prophylacting NRDS, and have no relationship with the means of administration.
