Idiopathic lymphoid interstitial pneumonia:a report of 3 cases and literature review
- VernacularTitle:成人特发性淋巴细胞性间质性肺炎三例并文献复习
- Author:
Bao CHEN
;
Huiping LI
;
Rongxuan ZHANG
;
Xianghua YI
;
Jingyun SHI
;
Jiang SHAO
- Publication Type:Journal Article
- Keywords:
Lung diseases,interstitial;
Pulmonary fibrosis
- From:
Chinese Journal of Internal Medicine
2008;47(6):486-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical,radiological and pathdogical characteristics of idiopathic lymphoid interstitial pneumonia (idiopathic LIP) and to discuss its diagnosis,treatment and prognosis.Methods Respiratory physicians,pathologists and radiologists together retrospectively analyzed the clinical,chest roentgenogram,computerized tomography,pathologicM,diagnostic and therapeutic data of 3 patients with idiopathic LIP confirmed by lung biopsy.and reviewed the relevant literatures.Results The major symptoms of the 3 cases of idiopathic LIP were prgressive dyspnea and dry cough.Higher levels of γ-globulins in serum were found in all the cases.The characteristic radiographic manifestations were bilateral diffuse nodules and cysts.The pathologic feature was diffuse interstitial inflammation with polyclonal lymphocytes infiltration,especially with plasma lymphocytes.Corticosteroids and cytotoxic agents were used and good response to therapy was observed in the cases.Conclusions Idiopathic LIP has some characteristics on the clinical,radiological and pathological features,but the best diagnostic method depends on a clinical-radiological-pathological approach.The disease usually shows good response to combinative therapy of corticosteroids and cytotoxic agents.
