Meningeal malignant melanosis:3 cases report with clinicopathological and neuroimaging
- VernacularTitle:脑膜恶性黑色素瘤病三例临床病理及神经影像学特点
- Author:
Xuewu LIU
;
Suqin LIU
;
Lijun SU
;
Chunyan HAO
;
Xiaomei DENG
;
Guoqing GAO
;
Xiuhe ZHAO
;
Wei WU
;
Zhaofu CHI
- Publication Type:Journal Article
- Keywords:
Meningeal neoplasms;
Melanoma;
Magnetic resonance imaging
- From:
Chinese Journal of Neurology
2008;41(5):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinicopathological and neuroimaging features of meninheal malignant melanosis.Methods The cytologic study of cerebrospinal fluid(CSF)and neuroimaging examination and meningeal histochemistry were performed in 3 cases of meningeal malignant melanosis. Results Three patients were found to have initial onsets of headache.followed by meningeal irritation.One case had huge malignant melanoma on skin.The second patient had diabrotic malignant melanoma on her face,which did not healed for a long time.The third patient had no malignant melanoma on skin and viscera.The MRI enhanced scanning of all 3 cases showed abnormal enhancement of meninge.There were a large number of abnormal shape cells in CSF.The meninxes were blackbrown or brown.The tumor cells were in various shapes with big and round irregular nucleus and rich cytoplasm.There were a great quantitv of melanosomes.The tumor cells were disarranged. Immunohistochemistry analyses found S-100 protein and Vim and HMB-45 were positive reaction. Conclusions The patients with meningeal malignant melanosis have an initial onset of headache,followed by meningeal irritation,and MRI enhanced scanning plays a valueble role in the diagnosis.A lage number of tumor cells in abnormal shape have been found in CSF.Thetumour cells of meninx presents different shapes with big and round or irregular nucleus.There are a great quantity of mellanosomes,and the tumour cells are arranged in a state of chaos.
