Electroencephalogram-functional magnetic resonance imaging study of the interictal epileptic activity in two patients with partial epilepsy
- VernacularTitle:部分性癫(癎)二例发作间期同步应用脑电图-功能磁共振成像定位致(癎)灶
- Author:
Yonghong LIU
;
Xuhong YANG
;
Wei LIAO
;
Ling LIU
;
Bo YAN
;
Xu LIN
;
Tianhua YANG
;
Hongru XU
;
Huafu CHEN
;
Dong ZHOU
- Publication Type:Journal Article
- Keywords:
Epilepsies,partial;
Seizures;
Electroencephalography;
Magnetic resonance imaging
- From:
Chinese Journal of Neurology
2008;41(5):313-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the map and pattern of blood oxygen level dependent(BOLD)signal changes correlated to interictal epileptiform discharges(IEDs)with EEG-fMRI in patients with partial epilepsy and then to explore the pathophysiological mechanisms of epileptic discharges and their effect on brain function in partial epilepsy.Methods Through the method of EEG-fMRI,2 patients with parial epilepsy were studied.The relationship between the regions of BOLD signal changes linked to IEDs and the electroelinical localization of epileptogenic zone in patients with partial epilepsy were investigated.Results The epileptogenic areas localized by electroclinical findings in the 2 patients all showed maximal activation and 2 sites of significant activation were found in 1 of the 2 patients;Weak activation were also manifested in the opposite side corresponding to lesions.Conclusions IED-linked BOLD response in patients with partial epilepsy is mainly in epileptogenic zones and weak activation can also be seen in the corresponding contralateral areas of epileptogenic zoiles.Activation areas ale well concordant with epileptogenie areas localized by electroclinical findings.
