C936T polymorphism in 3'-untranslated region of vascular endothelial growth factor gene is associated with diabetic nephropathy in type 2 diabetics
- VernacularTitle:血管内皮生长因子基因3'-非翻译区C936T多态性与2型糖尿病肾病相关
- Author:
Xinhuan ZHANG
;
Ying GUO
;
Lihong CHEN
;
Helin DING
;
Zuzhi FU
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Polymorphism;
single nucleotide;
Diabetes mellitus;
type 2;
Diabetic nephropathies
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):299-301
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between C936T polymorphism at 3'-untranslated region of vascular endothelial growth factor (VEGF) gene and diabetic nephropathy (DN) was analysed in 194 type 2 diabetic patients. The frequencies of genotype CC and allele C were significantly higher in DN group than those in non-DN group and control group. Allele C and genotype CC of VEGF may be a genetic marker susceptible to DN.
