Correlation between expression of COX-2,Ki-67 and neoadjuvant chemotherapy in breast cancer
- VernacularTitle:COX-2、Ki-67与乳腺癌新辅助化疗疗效的关系
- Author:
Fenglin CAI
;
Shifu ZHOU
;
Zhaosheng MA
;
Weifeng SHI
;
Yuyu WU
;
Weihong GAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ki-67 antigen;
Neoadjuvant chemotherapy;
COX-2
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(17):9-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between expression of COX-2,Ki-67 and neoadjuvant chemotherapy in breast cancer.Method COX-2 and Ki-67 were examined by immunohistochemical staining in 48 breast cancer samples.Results The overall response rate and clinical benefit rate to neoadjuvant chemotherapy were 70.8% and 95.8%,respectively.The expression of COX-2 and Ki-67 after the chemothempy [41.7% and (33.23±18.11)%] was significantly lower than those in prechemotherapy [62.5% and (46.81±23.17)%],P<0.05.Ki-67 index Was higher in COX-2 positive tumom than that in the COX-2 negative ones before and after neoadjuvant chemotherapy,P<0.01.The effect of neoadjuvant chemotherapy had a significantly negative correlation with COX-2 expression.Patients with high expression of Ki-67 were more likely to respond to treatment.Conclusion The expression of COX-2 and Ki-67 as molecular markers could be a guide for chemotherapy and prediction for neoadjuvant's response to chemotherapy in breast cancer.
