Effect of caloric restriction at early age of rats on their isletβcell function in adulthood
- VernacularTitle:幼年大鼠热卡限制对成年后胰岛β细胞功能的影响
- Author:
Xiaoyi HE
;
Yu HU
;
Xiaolong ZHAO
- Publication Type:Journal Article
- Keywords:
Calorie restriction;
Rats;
Pancreatic β cell function;
Superoxide dismutase;
Malonaldehyde
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):318-319
- CountryChina
- Language:Chinese
-
Abstract:
Eleven-week-old SD rats were randomized into control and calorie restriction group. The pancreatic β cell function and oxidative stress indexes in the two groups were compared after 24-week intervention. The results showed that calorie restriction, which started from young age, improved the early insulin secretion after glucose loading and alleviated the oxidative stress in adult rats, which wag related to the reduction of body weight.
