Effect of pentoxifylline on Fas and FasL expressions in pancreas and spleen of NOD mice
- VernacularTitle:己酮可可碱对NOD小鼠胰腺、脾脏Fas和FasL表达的影响
- Author:
Liping GU
;
Yijie WU
;
Yufei WANG
;
Nianwei SHI
;
Weiping DONG
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Diabetes mellitus;
type l;
Mice;
inbred NOD;
Fas;
FasL
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):322-323
- CountryChina
- Language:Chinese
-
Abstract:
NOD mice were treated with pentoxifylline (FTX) to investigate the incidence of cyclophosphamide-accelerated diabetes, the apoptosis and the insulin expression of β-cells and expressions of Fas or FasL mRNA in both pancreas and spleen. The results showed that incidence of diabetes in PTX group was significantly lower compared with control group (P<0.05). The apoptosis of β-cells was decreased in PTX group with higher insulin expression level in islet cells. The expression of FasL mRNA in pancreas of PTX group was lower than that of control group (P<0.05), and there was no significant difference in Fas mRNA expression between two groups. Both Fas and FasL mRNA levels in spleen of PTX group were much higher than those of control group (P<0.05 or P<0.01).
