Effect of hepatocyte growth factor on peripheral nerve regeneration
- VernacularTitle:肝细胞生长因子修复周围神经损伤研究
- Author:
Zhi LI
;
Shibi LU
;
Mingxue SUN
;
Jiang PENG
;
Li ZHANG
;
Xiang SUI
;
Bin ZHAO
- Publication Type:Journal Article
- Keywords:
Peripheral nerve;
Nerve regeneration;
Hepatocyte growth factor;
Contusion
- From:
Chinese Journal of Trauma
2008;24(6):411-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hepatocyte growth factor on peripheral nerve regeneration. Methods Sciatic nerve contusion injury was made by a custom-made clamp in Wistar rats,in which human hepatocyte growth factor expressed by adenoviral vector(Ad-HGF)was injected into the muscle around the injured nerve.The results of nerve regeneration were evaluated by sciatic nerve function index(SFI),muscle wet weight,neural electrophysiology and image analysis. Results Four weeks after sciatic nerve injury,the results of sciatic nerve function index(SFI),muscle wet weight,neural electrophysiology and image analysis showed better nerve regeneration in group injected with HGF than control group(P<0.05). Conclusion Hepatocyte growth factor can promote axon regeneration and functional recovery and is an effective neurotrophic factor for peripheral nerve regeneration after injury.
