Study on the correlation of serum insulin-like growth factor-1 and radioactive iodine uptake rate in patients with nodular goiter
- VernacularTitle:结节性甲状腺肿血清胰岛素样生长因子-1水平与摄131Ⅰ率相关性研究
- Author:
Guangjie SONG
;
Jinjun LIU
;
Hongjiang ZHU
;
Xueqing YU
;
Yingxian LI
;
Cuishi TIAN
- Publication Type:Journal Article
- Keywords:
Goiter,nodular;
Insulin-like growth factor 1;
Radioactive iodine uptake rate
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(17):12-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of the serum insulin-like growth factor-1(IGF-1) level and the radioactive iodine uptake rate in patients with nodular goiter,to explore a simple and saftymethods of identifying different kinds of thyroid nodule.Methods Sixty diagnosed cases was selected intohot nodule group(30 cases)and cool nodule group(30 cases),and 30 healthy people were selected into thehealthy control group.Measured the IGF-1,FT3,FT4,TSH level of each group by radioimmunoassay,and measured the radioactive iodine uptake rate by radionuclear technique.Results To compare with healthy control group,the levels of serum IGF-1,FT3,FT4 and the radioactive iodine uptake rate of hot nodule group were increased obviously,but the serum TSH was decreased significantly,and the level of IGF-1 had positive correhtion with the radioactive iodine uptake rate(r=0.835)in the same group.Meanwhile,the 1 evel of IGF-1 had negative correlation with the level of TSH(r=-0.326).In cool nodule group,the levels of serum IGF-1,FT3,FT4,TSH had no significant difference oompared with healthy control group(P>0.05).Conclusion The level of IGF-1 and radioactive iodine uptake rate in patients with nodular goiter has certain correlation.
