Change and significance of plasma surfactant protein D level in patients with severe multiple trauma combined with acute lung injury
- VernacularTitle:严重多发伤并发急性肺损伤患者血浆中肺表面活性物质相关蛋白D的变化及意义
- Author:
Baiyun WANG
;
Daomiao XU
- Publication Type:Journal Article
- Keywords:
Multiple trauma;
Acute lunge injury;
Acute respiratory distress syndrome;
Surfactant-associated protein D
- From:
Chinese Journal of Trauma
2008;24(6):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To dynamically measure level of surfactant protein D(SP-D)in patients with severe multiple trauma and discuss the relationship between SP-D and acute lung injury(ALI)/ARDS and its clinical significance. Methods A total of 36 patients with severe multiple trauma were divided into ALI/ARDS group(20 patients)and non-ALI/ARDS group(16 patients).Peripheral blood samples were collected at days 1,3,7 and 14 after trauma for calculating lung injury score(LIS)and PaO2/FiO2 ratio.Another 12 healthy persons were served as control group.Plasma SP-D levels were measured by using enzyme linked immunoabsorbent assay(ELISA). Results The plasma SP-D levels in ALI/ARDS group were markedly higher than those of control group and non-ALI/ARDS group(P<0.01).In ALI/ARDS group,the plasma SP-D levels in severe lung injury group were significantly higher than those of modcrate lung injury group(P<0.05).The plasma SP-D levels in ALI/ARDS group were inversely related to their PaO2/FiO2 ratios(rs=-0.745,P<0.01). Conclusions The plasma SP-D level is relevant not only to the occurrence of traumatic ALI/ARDS after multiple trauma,but also closely to the severity of lung injury,indicating that plasma SP-D is a valuable biomarker in ALI/ARDS.
