Differential expression of poroteome in brain tissues from rats with severe traumatic brain injury
- VernacularTitle:重型脑损伤大鼠脑组织蛋白质组差异表达
- Author:
Sai ZHANG
;
Zhenlin LIU
;
Hongtao SUN
;
Qunliang HU
;
Shizhong SUN
;
Xiaozhi LIU
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Two-dimensional gel dectrophoresis;
Proteome
- From:
Chinese Journal of Trauma
2008;24(6):425-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of proteome expression in brain tissues from rats with severe traumatic brain injury(sTBI). Methods Total protein of brain tissues were obtained at days 3,7 and 14 for two-dimensional gel electrophoresis to screen and identify differential protein spots.Results We screened 17 differential protein spots that were involved in cellular metabolism,stress and inflammatory reaction. Conclusion Some differential proteins involved in sTBI can be found by twodimensional gel electrophoresis.
