Early mortality of patients with spontaneously ruptured hepatocellular carcinoma: risk factors and treatment regimens
- VernacularTitle:肝癌自发破裂早期死亡危险因素分析及治疗
- Author:
Xufeng ZHANG
;
Yi LU
;
Chang LIU
;
Liang YU
;
Bo WANG
;
Xuemin LIU
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Spontaneous rupture
- From:
Chinese Journal of Digestive Surgery
2008;7(3):189-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors associated with early mortality (within 30 days) of patients with spontaneously ruptured hepatocellular carcinoma (SRHCC) and assess the efficacies of different treatment regimens. Methods The clinical data of 28 patients with SRHCC who had been admitted to our hospital from January 1999 to January 2006 were retrospectively analyzed. Multiple factors that might cause early mortality were determined, and the efficacies of different treatment regimens were assessed. Results Eleven patients died within 30 days. with the mortality rate of 39%. Univariate analysis showed that shock, Child C status, hemoglobin. ALT, and volume of blood transfusion were associated with early mortality (X2=3.020, 13.741, Z=-2.059, -2.210, -4.153, P<0.05). Child C status and volume of blood transfusion were the independent risk factors. All the patients were divided into hepatectomy group (8 cases), surgical hemostasis group (7 cases), transarterial embolization group (7 cases) and conservative group (6 cases). Patients in hepatectomy group had a better 30-day and median time survival rate compared with those in the other 3 groups (X2=8.098, 8.098, 15.025, Z=-3.127, -2.840, -3.004, P<0.05). Conclusions Poor hepatic functional reserve and severe hemorrhage are closely associated with early mortality of patients with SRHCC. Hepatectomy is a better choice for SRHCC.
