Intra-Arterial Thrombolysis with Urokinase in Patients with Acute Ischemic Stroke:A Clinical Observation
- VernacularTitle:急性缺血性卒中患者尿激酶动脉溶栓治疗的临床观察
- Author:
Junshan ZHOU
;
Jiandong JIANG
;
Jingtao WANG
;
Jie YANG
;
Liang CHEN
;
Jianping GU
- Publication Type:Journal Article
- Keywords:
intra-arterial thrombolysis;
urokimse;
ischemic stroke
- From:
International Journal of Cerebrovascular Diseases
2008;16(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of selective intra-arterial thrombolysis with urokirmse for acute cerebral infarction.Methods:Thirty-eight patients with acute cerebral infarction were treated by selective intra-arterial thrombolysis with urokinase within 6 hours of onset.Head CT seans were performed immediately and 24 hours after the procedures to find out whether intracerebral hemorrhage(ICH)had occurred.The activities of daily living and functional outcome of the patients were evaluated by the Barthel Index(BI)and the National Institutes of Health Stroke Scale(NmSS).Results:Of the 38 patients,21 achieved complete recanalization,8 achieved partial recanalization,3 occurred symptomatic intracranial hemorrhage,and l died.At day 90,22 patients had a favorable outcome(BI≥90),11(50≤BI＜90)had a better outcome,and 4 had a worse one(BI＜50);at 6 months,24 patients had a favorable outcome,9 had a better outcome.and 4 had a worse one.The NIHSS scores at day 14 after the procedures were significantly superior to the levels betore the procedures(12.68±7.43 versus 15.38±4.32,P＜0.011.Conclusions: Intra-arterial thrombolysis with urokinase can recanalize the occluded vessels and improve the acute clinical symptoms and long-term prognosis of patients.
