Rho/Rho-Kinase Signaling Pathway and Ischemic Cerebrovascular Disease
- VernacularTitle:Rho/Rho激酶信号通路与缺血性脑血管病
- Author:
Zhi WANG
;
Bingzhen CAO
- Publication Type:Journal Article
- Keywords:
Rho/Rho-kimse,ischemic cerebrovascular disease;
brain injury;
endothelium
- From:
International Journal of Cerebrovascular Diseases
2008;16(5):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Rho/Rho-kinase signaling pathway is a ubiquitous one in vivo.It plays a role of "molecular switch"by regulating the polymeric state of intracellular actin cytoskeleton,and participates in the regulation of various cellular functions.Rho/Rho-kinase signaling pathway plays an important role in the risk factors.pathogenesis and pathophysiological processes of ischemic cerebrovascular disease.The inhibition of Rho/Rho-kinase signaling pathway may achieve a significant neuroprotective effect.
