Association between serum level of interleukin-18 and insulin resistance in women with polycystic ovary syndrome
- VernacularTitle:多囊卵巢综合征患者血清白细胞介素18与胰岛素抵抗相关
- Author:
Yifei ZHANG
;
Yisheng YANG
;
Jie HONG
;
Weiqiong GU
;
Chunfang SHEN
;
Min XU
;
Pengfei DU
;
Xiaoying LI
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Interleukin-18;
Polycystic ovary syndrome;
Insulin resistance;
Euglycemic hyperinsulinemic clamp
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):278-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between interleukin-18(IL-18) and insulin resistance, measured by euglycemic hyperinsulinemic clamp, in women with polycystic ovary syndrome (PCOS). Methods Forty-two young women with PCOS and 38 age-and body mass index (BMI)- matched control women were recruited in this study. A complete hormonal assay was performed and serum IL-18 level was determined in each subject. And euglycemic hyperinsulinemic clamp test was completed in 41 of the above subjects. Results Serum IL-18 levels were increased in the PCOS women, as compared with the control (P=0.033). When all subjects were divided into lean and obese groups, the IL-18 levels were slightly increased in the obese subjects (P=0.902). IL-18 levels were negatively correlated with all the clamp parameters [mean glucose infusion rate (M), M-to-insulin ratio (M/I) and glucose metabolic clearance rate (MCRg), r =-0.419,-0.396,and-0.405,P=0.006,0.010 and 0.009 respectively], but were positively associated with HOMA-β index(r=0.334, P=O.035). Conclusion Serum IL-18 level was significantly increased in PCOS women and was strongly associated with the parameters obtained from the euglycemic hyperinsulinemic clamp, indicating that IL-18 may be an important mediator between inflammation and insulin resistance.
