Investigation of retinoic acid in dedifferentiated thyroid carcinoma induction
- VernacularTitle:维甲酸诱导失分化型甲状腺癌的观察
- Author:
Gengbiao YUAN
;
Anren KUANG
;
Qun FAN
;
Xing GUO
;
Quanlin WANG
;
Changtian GUAN
;
Nan YU
- Publication Type:Journal Article
- Keywords:
All trans retinoic acid;
Dedifferentiated thyroid carcinoma;
Induction;
Toxicity
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(3):295-296
- CountryChina
- Language:Chinese
-
Abstract:
The patients with dedifferentiated thyroid carcinoma were induced by all-trans retinoic acid (ATRA). The treatment was effective in 5 patients (5/9,55.6%), and 5 patients were benefited from following 131 I treatment(5/8, 62.5% ). Three patients(3/12,25.0% ) quitted because of neurological side-effects. It is efficacious to apply ATRA to induce dedifferentiated thyroid carcinoma and improve radio-iodine uptake and acquire benefit for patients, but clinic application of ATRA must be cautious.
