Relationship Between Plasma Fibrinogen Level and Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation
- VernacularTitle:非瓣膜性心房颤动患者血浆纤维蛋白原水平与缺血性卒中的关系
- Author:
Xiaojun DING
;
Linlin QIU
;
Xueqing LIU
;
Liwei GAO
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
fibrinogen;
ischemic stroke
- From:
International Journal of Cerebrovascular Diseases
2008;16(5):329-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the increased plasma fibrinogen level is an independent predictor of cardiogenic embolism in patients with nonvalvular atrial fibrillation (NVAF).Methods:Ninety-eight patients with NVAF hospitalized for cardiac causes were evaluated,and 24 of them had a history of ischemic stroke.The relationship between fasting plasma fibrinogen level and ischemic stroke were analyzed.Results:After adjusting traditional cardiovascular risk factors.the patients with NVAF who had the history of ischemic stroke were significantly older than those without(mean [SD] age 73.6 [8.4]vs.69.1[10.3] years,P=0.017).1he prevalence of hypertension was significantly higher(83.3%va.66.2%,P=0.011).The proportion of patients with left ventricular systolic dysfunction was significantly higher(63.1% vs.45.9%,P=0.006),and plasma fibrinogen level increased significantly (mean [SD] 365 [108]vs.312[82] mg/dL,P=0.008).Conclusions:Plasma fibrinogen level is independently associated with a history of ischemic stroke in older patients with NVAF hospitalized for cardiac causes.
