The expression and clinical significance of Survivin and Ki-67 in breast carcinoma
- VernacularTitle:乳腺癌中Survivin和Ki-67的表达及其临床意义
- Author:
Lei ZHONG
;
Jianguo ZHANG
;
Baoliang GUO
;
Xi CHEN
;
Guoqing LUO
;
Zhigang LI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ki-67 antigen;
Survivin;
Immunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(17):3-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Survivin and Ki-67 in breast carcinoma,and explore their correlation.Method The expression of Survivin and Ki-67 in breast carcinoma(49 cases)and normal breast tissues(12 cases)were examined by immunohistochemical method.Results The positive expression rates of Survivin and Ki-67 in breast carcinoma were significantly higher than those in normal breast tissues(P<0.05).The expression of Survivin was significantly related to clinical stage and lymph node metastasis(P<0.05).The expression of Ki-67 Was significantly related to clinical stage,lymph node metastasis,and pathological grade(P<0.05).The expression of Survivin was obviously related with Ki-67 in breast carcinoma(r=0.734,P<0.05).Conclusions The overexpression of Survivin and Ki-67 may play a cooperative role in the occurrence and development of breast carcinoma.They may serve as useful markers for assessment of biological behavior of breast carcinoma.
