An Experimental Study on Comedogenicity of Several External Contactants.
- Author:
Hwa Yung AHN
;
Ki Bum MYUNG
;
Jeong Hee HAHM
;
Hong Il KOOK
- Publication Type:Original Article
- Keywords:
Comedogenicity
- MeSH:
Betamethasone;
Corn Oil;
Ear Canal;
Lactic Acid;
Lanolin;
Myristic Acid;
Olea;
Oleic Acid;
Petrolatum;
Plant Oils;
Polyethylene Glycols;
Polysorbates;
Propylene Glycol;
Rabbits;
Sesame Oil;
Sodium Dodecyl Sulfate;
Squalene;
Sulfur;
Olive Oil
- From:Korean Journal of Dermatology
1985;23(5):620-629
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was performed to evaluate the comedogenicity of several cosmetic ingredients, vegetable oils, steroid and sulfur. The test materials were applied to one ear canal of rabbits for 6 weekdays for 2 weeks. The results were as follows: l. Among the 14 cosmetic ingredients, no comedogenicity was shown in propylene glycol and petrolatum, mild comedogencity in squalene, acetylated lanolin, polyethylene glycol, cetyl aIcohol and Tween 80. Propylene glycol, sodium lauryl sulfate and oleic acid showed moderate comedogenicity. Severe comedogenicity was observed in myristyl myristate, isopropyl myristate, butyl stearate and myristyl lactate. 2. Moderate to severe comedogenicity was shown in olive oil, sesame oil and corn oil and moderate comedogenicity in sulfur (8%) and betamethasone dipropionate (0.06%) R. Histopathologic grading were paralleled the findings of the naked eye.
