Mechanism of regulatory T cell-induced tumor immune tolerance
- VernacularTitle:调节性T细胞诱导肿瘤免疫耐受的机制
- Author:
Wenjie XIE
;
Hongzhen YANG
- Publication Type:Journal Article
- Keywords:
CD4+ CD25+ regulatory T cell;
Tumor;
Immune tolerance
- From:
Journal of International Oncology
2008;35(6):403-406
- CountryChina
- Language:Chinese
-
Abstract:
regulatory T cell(Treg)is a subset of immunosuppressive Th cell lines with ability to sup-press anti-tumor immunity. Tregs are recruited into local tumor microenvironment by tumor-released chemokine CCL22. Tregs induce Th2-type immune responses which contribute the host ignorance and tolerance to tumor cells via releasing of immunosuppressive cytokines and immunosuppressive receptors. Accumulating evidences indicate that inhibiting Treg can break immune tolerance,and subsequently inhibit the growth and progress of cancer. These discoveries and exploration of Treg provide us a new therapeutic target and strategy with promising clinic application.
