Neuroglobin and Cerebral Hypoxia/Ischemia Cerebral Injury
- VernacularTitle:脑红蛋白与缺血缺氧性脑损伤
- Author:
Jing YIN
;
Yi YANG
;
Litao LI
;
Xiangjian ZHANG
- Publication Type:Journal Article
- Keywords:
neuroglogin;
hypoxia/ischemia;
brain injury;
neruroprotection
- From:
International Journal of Cerebrovascular Diseases
2008;16(5):380-383
- CountryChina
- Language:Chinese
-
Abstract:
Neuroglobin(Ngb)is one of the members of oxygen-carrying globin family.It mainly exists in neurons in a monomeric form,which is closely correlated the oxygen supply to brain.Brain hypoxia/ischemia can induce the high expression of Ngb,and as an endogenous neuroprotective factor,it protects ischemic neurons from ischemia/hypoxia injury.This article reviews the distribution,structure and function of Ngb,and its potential protective effects and mechanisms in cerebral ischemia/hypoxia cerebral injury.
