TNEAK-Fn14 Pathway and Central Nervous System
- VernacularTitle:TWEAK-Fn14通路与中枢神经系统
- Author:
Ying LIU
;
Chenhui YANG
;
Hongguang FAN
;
Xiangjian ZHANG
- Publication Type:Journal Article
- Keywords:
TWEAK-Fn14;
central nervous system;
inflammation;
blood-brain barrier;
ischemic stroke;
multiple sclerosis;
gliocytoma
- From:
International Journal of Cerebrovascular Diseases
2008;16(5):384-387
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-like weak inducer of apoptosis(TWEAK)is a new member of the tumor necrosis factor family.After TWEAK binding to its receptor Fn14.it induces extensive biological activities.TWEAK-Fn14 pathway participates in pathophysiological mechanisms of cell apoptosis,regulation of the blood-brain barrier permeability and inflammation in central nervous system,and it is closely correlated with the diseases such as ischernic stroke.multiple sclerosis and gliocytoma.
