Lectin-like oxidized low density lipoprotein receptor-1 mediates effects of bezatibrate on the apoptosis of endothelial cells
- VernacularTitle:LOX-1介导苯扎贝特对内皮细胞凋亡的影响
- Author:
Xiaoyu SHEN
;
Lixia XUE
;
Qiaofang QU
;
Qiutang ZENG
- Publication Type:Journal Article
- Keywords:
Bezafibrate/PD;
Receptors,LDL;
Apoptosis
- From:
Journal of Chinese Physician
2008;10(6):754-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of bezafibrate on the apoptosis and expression of lectin-like oxidized low density lipoprotein receptor-1(LOX-1) mediated by oxidized low density lipoprotein(ox-LDL) in cultured human umbilical vein endothelial cells(HUVECs).Methodes The apoptosis of HUVECs mediated by ox-LDL were evaluated by flow cytometry and the expression of LOX-1 mRNA were detected by RT-PCR.Results Compared with the control group,ox-LDL could increase apoptosis and the expression of LOX-1(P<0.05),and Bezafibrate could decrease the apoptosis and the expression of LOX-1 in a concentration -dependent manner(P<0.05).Preincubation of HUVECs with polyinosinic acid for 2 hours,the apoptosis and the expression of LOX-1 decreased(P<0.05).Conclusions Bezafibrate inhibits the apoptosis of HUVECs mediated by ox-LDL by reducing the expression of LOX-1,which may be part of the reasons for bezafibrate to prevent and treat atherosclerosis.
