Identification of two newly discovered subgenotypes of hepatitis B virus genotype C
- VernacularTitle:两种新发现的乙型肝炎病毒/C基因亚型的鉴定
- Author:
Bin ZHOU
;
Zhanhui WANG
;
Shujuan WEN
;
Jinjun CHEN
;
Jian SUN
;
Jinlin HOU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Genotype;
Recombination,genetic Gene amplification;
Sequence analysis
- From:
Chinese Journal of Infectious Diseases
2008;26(6):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the genotypic characteristics of hepatitis B virus (HBV)C/D recombinant of two types of newly discovered HBV genotypea found in Western China.Methods The whole genomes of 17 HBV strains isolated from Western China were amplified by polymerase chain reaction (PCR). Bioinformatic softwares were used for the analysis of full genome structure,genetic distances and recombination points.Results The heterogenicity of the HBV C/D recombinant was more than 8% compared with genotype A,B,D,E or F,but 3.8% 0A-8.O% compared with genotype C Based on phylogenetie analysis, a11 C/D recombinant strains clustered within genotype C.but were rouped into two other clusters within the genotype C independently from C1-C5 subgenotypes,which were two kinds of new HBV/C genotypea.Condusion The HBV C/D recombinant could he considered as tWO kinds of new subgenotypea of HBV genotype C which are different from subgenotype C1-C5 based on the genetic distances analysis.
