Indicators of predicting sensitivity of preoperative concurrent radiochemotherapy for rectal cancer
- VernacularTitle:预测直肠癌术前同步放化疗敏感性的指示剂
- Author:
Jialin LUO
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Drug therapy;
Radiotherapy
- From:
Journal of International Oncology
2008;35(6):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Preoperative radiochemotherapy for locally advanced rectal cancer can improve local control rate obviously and ameliorate survival rate for pathologically complete response. However the clinical response is different among patients. Recently, clinical study and basic research results suggest survivin, p53/p21, telom-erase, growth hormone receptor(GHR), ku70, Bax, Bcl-2, Ki67 and vascular endothelial growth factor (VEGF) are related to the sensitivity of preoperative concurrent radiochemotherapy. They can be used to pre-dict sensitivity of preoperative radiochemotherapy.
