Dynamic changes of HSP70 mRNA expression in liver tissue of rats with traumatic shock and the treatment effects of glycine
- VernacularTitle:创伤性休克大鼠肝组织HSPT0 mRNA表达变化及甘氨酸的干预影响
- Author:
Zhe DENG
;
Dehong LIU
;
Yugang XIE
;
Zhongjiang ZHAO
;
Yiwu SUN
;
Zheqiang ZHOU
;
Bin YAO
;
Min QIU
;
Weidong WANG
- Publication Type:Journal Article
- Keywords:
Shock,Traumatic;
Heat-shock proteins 70;
Glycine/PD
- From:
Journal of Chinese Physician
2008;10(6):739-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes of HSP70 mRNA expression in the liver tissue of rats with traumatic shock and the treatment effects of glycine.Methods The expression of HSP70 mRNA in the liver tissue of treatment group,shock group and control group was detected by ELISA.Pathological changes were observed,and serum ALT and AST were measured.Results The expression of HSP70 mRNA in the liver tissue of rats in the shock group and the treatment group reached peak at the 6th and 12th hour after resuscitation respectively.Serum ALT and AST increased and pathological damage aggravated with time prolonging.Compared with control group,the expression of HSPT0 mRNA in treatment group increased significantly,serum ALT and AST decreased significantly and pathologi- cal damage was significantly relieved(all P<0.05).Conclusion Glycine can increase the expression of HSPT0 mRNA and relieve the secondary damage of liver after traumatic shock.
