Changes of P-selectin and D-dimer in acute patients with deep venous thrombosis
- VernacularTitle:急性下肢深静脉血栓形成P-选择素与D-二聚体的变化及意义
- Author:
Jiang WU
;
Fusheng WANG
- Publication Type:Journal Article
- Keywords:
deep venous thrombosis;
P-seleetin;
D-dimer
- From:
International Journal of Surgery
2008;35(7):460-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the statues of P-selectin and chang of D-dimer in vivo in patients with deep venous thrombosis(DVT)and to observe how to vary under interneving of medicines.Methods P-selectin and D-dimer of fourty patients and twenty normal subjects were fluo-rescencelabled with its corresponding monoclonal antibodies by flow cytometry(FCM)and immune method respectively.Results In the early stage,P-selectin and D-dimer of patients with DVT is higher than that in normals,and they significantly decreased in different time after patients were treated.Compared with patients who were used on-sodium ozagrel,patients used sodium ozagrel have different P-selectin(P＜0.05),but D-dimer was similar(P＞0.05)after fourteen days.One month later,P-selectin and D-dimer of DVT patients were lower.However,the positive rate of P-selectin of DVT was still higher than normal subjects.Conclusions The platelet has been actived in vivo in patients with DVT,so do fibrinolysis.Sodium ozagrel can decrease the action of platelet.P-selectin and D-dimmer may be used in diagnose.Post-discharge patients are still high-risk group and must be followed-up regularly.
