Effect of thymosin α1 on immunologic function and cytokines in Patients with severe infection
- VernacularTitle:胸腺肽α1对严重外科感染患者免疫功能和炎症细胞因子的影响
- Author:
Xiaoqiang HAN
;
Yunxia LEI
;
Keqiang SHI
- Publication Type:Journal Article
- Keywords:
thymosin;
immunologic function;
cytokine
- From:
International Journal of Surgery
2008;35(7):462-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of thymosin α1 on immun ologic function and cytokines in the abdominal sepsis patients.and naddiscuss the therapeutic function of thymoin α1 in sepsis.Methods Thirty-eight sepsis patients admitted between May 2006 and May 2007 in the Hospital of Weifang Medical University.Patients were divided into the treatment group(20 cases)and control group(18 cases)randomly.Thymosin α1 was used in the treatment group on the basis of infection controlled.The concentration of cytokines(TNF-α,IL-6,IL-10)and the percent age of CD3,CD4,NK cell were observed.Results The concentrations of TNF-α and IL-6 were increased significantly in bothgoups.But it was more prominently in the control group.The concentration of IL-10 and the percent age of CD3,CD4,NK cell increased more significantly in thymosinod treatment group than those in the control group.Conclusions Thymosincd canmodulate the release of TNF-α,IL-6,IL-10 and mitigate the inflammatory reaction,which may improve the immunologic function.
