Altered tumor antigen peptide vaccines and their application in oncotherapy
- VernacularTitle:修饰的肿瘤抗原肽疫苗及其在肿瘤治疗中的应用
- Author:
Jing LIU
- Publication Type:Journal Article
- Keywords:
Cancer vaccine;
Antigenic peptide;
Protein alteration
- From:
Journal of International Oncology
2008;35(6):417-420
- CountryChina
- Language:Chinese
-
Abstract:
Tumor antigenic peptide vaccines,which have been adapted with altered peptide ligand (APL) and adjuvant to improve cytotoxic T lymphocyte response,include vaccines of different originations. These vaccines are orginated from malignant melanoma differentiation, HER2, NY- ESO-1, carcinoembryonic antigen and etc. Recently,great advances have been made in the related alteration methods,peptide designing principles and cytotoxic T lymphocyte response improvement mechanisms of these peptide vaccines. Furthermore,the vac- cines are showing satisfying pedormances in clinical treatments.
