Changes of excitatory amino acids of cerebrospinal fluid in patients with delayed encephalopathy after acute carbon monoxide poisoning
- VernacularTitle:急性一氧化碳中毒迟发脑病脑脊液中兴奋性氨基酸水平的变化
- Author:
Weina WANG
;
Feiyan YUAN
;
Anmin JIN
;
Yu LIU
- Publication Type:Journal Article
- Keywords:
Carbon monoxide poisoning;
Brain disease;
Excitatory amino acids;
Cerebrospinal fluid
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(19):14-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of excitatory amino acids (EAAs) of cerebrospinalfluid (CSF) in patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Method The EAAs levels of CSF including glutamate (Glu) and aspartate (Asp) in 24 patients with DEACMP and 20 controls with migraine were measured by high performance liquid chromatography( HPLC ).Results Glu and Asp levels in patients with DEACMP were significantly higher than those of the controls [(3.76 ± 1.52) μmol/L vs ( 1.55 ± 1.03 ) μmol/L, (0.73 ± 0.44) μmol/L vs (0.38 ± 0.33 ) μmol/L, P all <0.01]. Glu and Asp levels in moderate and severe DEACMP patients were higher than those in mild DEACMP patients. Conclusion It suggests that EAAs participated in the pathogenesis of DEACMP. The Glu and Asp levels in CSF may be regarded as indicator of DEACMP.
