The clinical significance of autoantibodies against acetylcholine muscarinic 3 receptor in primary Sj(o)gren's Syndrome
- VernacularTitle:抗乙酰胆碱3受体抗体在原发性干燥综合征中的临床意义
- Author:
Ying WU
;
Mengtao LI
;
Yan ZHAO
;
Sheng FENG
;
Li SU
;
Yi DONG
- Publication Type:Journal Article
- Keywords:
Primary Sj(o)gren's syndrome;
Anti-M3 receptor antibody
- From:
Chinese Journal of Internal Medicine
2008;47(7):563-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect anti-M3 receptor antibodies in primary Sj(o)gren's syndrome(pSS)patients and to explore its association with clinical manifestations.Methods Anti-M3 antibodies were tested in 70 patients with pSS,50 patients with systemic lupus erythematosus(SLE)and 76 normal controls with ELISA and Western blot.The correlation between anti-M3 antibodies and other clinical manifestations was analyzed.Results (1)The positive rate of anti-M3 antibodies in pSS Was 47.14% using ELISA and 60.00% using Western blot in SLE 4.00% using ELISA and 12.00% using Western blot and in normal controls 14.47% using ELISA and 15.79% using Western blot.(2)The incidence of sehirmer test,tear break-up time(BUT),whole saliva flow rate,punctate epithelial erosions(PEE)on the corneas and external eye examination were not significantly different between the anti-M3 positive and negative groups.(3)The incidences of IgG,rheumatoid factor,SSB and fluorescence index(FI)＞3 were higher in the positive group than in the negative group using EUSA.Conclusion The positive rate of anti-M3 antibodies is higher in pSS than in SLE and normal controls and in some degree it has correlation with the lesion in salivary gland.
